Umpires needed a few minutes to review Verdugo's drive, which bounced off the low wall in right field just short of Pesky's Pole, before officially declaring it a hit and the game over.
Nick Gordon hit his first career grand slam and drove in a career-high six runs, Jake Cave and Gary Sánchez also homered, and the Twins beat the Red Sox 10-5.
The Twins outscored the Giants 20-5 in the series and have won three straight following a six-game losing streak that knocked them out of first place in the AL Central.
David Ortiz was elected to the Baseball Hall of Fame in his first turn on the ballot, while steroid-tainted stars Barry Bonds and Roger Clemens were denied entry to Cooperstown